PhD position – membrane protein research at IBPC, Germany

The Institute of Biophysical Chemistry (IBPC) at the University of Frankfurt/Main is offering research opportunities in membrane protein research combined with new cell-free expression and nanodisc technologies. The successful candidate will participate in a BMBF funded project on the cell-free production of membrane proteins with focus on human G-protein coupled receptors and other pharmaceutical relevant targets. The project will be carried out in close collaboration with the Fraunhofer Institute for Biomedical Technology in Potsdam and with industrial partners. Key techniques will be preparative scale cell-free expression systems based on prokaryotic and eukaryotic extracts, the nanodisc technology, automated throughput screening techniques, Biacore analysis, functional assays for membrane proteins and structural approaches by high resolution NMR spectroscopy. All relevant techniques including efficient cell-free production protocols for the selected targets have already been established at the IBPC.

Applicants should hold a diploma in biology or biochemistry together with a sound background in molecular biology and in standard biochemical techniques. Experience with membrane proteins will be a plus but is not essential.

The IBPC is located at the biocentre of the Goethe-University Frankfurt (Campus Riedberg) which provides excellent facilities for membrane protein research. The Campus Riedberg is a dynamic centre for life sciences research with an international and highly interactive scientific community. The campus hosts several science clusters like the Centre of Membrane Proteomics (www.cmp.uni-frankfurt.de), the Cluster of Excellence “Macromolecular Complexes” (www.cef-mc.de) and the Centre of Biomolecular Resonance (www.bmrz.uni-frankfurt.de). The IBPC operates an European Large Scale NMR facility and it is core centre of the INSTRUCT (Integrated Biology, www.structuralbiology,eu) community providing cell-free expression platforms.

Applicants should submit a detailed CV including abstracts of the diploma thesis, a description of research experience and interests and a method profile.

Applications should be sent by email to:
Dr. Frank Bernhard, Institute of Biophysical Chemistry, University of Frankfurt
Max-von-Laue-Str. 9, 60438 Frankfurt.

fbern@bpc.uni-frankfurt.de

SummaryThe Institute of Biophysical Chemistry (IBPC) at the University of Frankfurt/Main is offering research opportunities in membrane protein research combined with new cell-free expression and nanodisc technologies. The successful candidate will participate in a BMBF funded project on the cell-free production of membrane proteins with focus on human G-protein coupled receptors and other pharmaceutical relevant.